Developing an antibody to combat age-related muscle atrophy

As we age, our muscles atrophy. Earlier this year, researchers found that hepatocyte growth factor (HGF), a protein critical in skeletal muscle development loses its functionality due to nitration as we age. Now, the same team has developed a monoclonal antibody that blocks the nitration sites of HGF, effectively preventing the protein’s age induced loss of function. Their findings were validated utilizing rat muscles cell culture.
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